The following players went from the Hanshin Tigers to the majors for an attempt at stardom. The years in brackets indicates their tenure with Hanshin. This list does not include import players who started in America, made their way to Japan, and returned to MLB afterward. You can find many of them here.
Tsuyoshi Shinjo (1990-2000) – to New York Mets
Keiichi Yabu (1994-2004) – to Oakland Athletics
The following players left NPB for the majors and signed with Hanshin upon their return to Japan. The years in brackets indicates their tenure with Hanshin.
Hideki Irabu (2003-04) – from Texas Rangers
Yoshinori Tateyama (2014) – from New York Yankees